Tofanib XR 11 mg Tablet

Manufacturer : Globe Pharmaceuticals Ltd Tofacitinib is indicated for the treatment of adult patients with moderate to severely active rheumatoid arthritis who have not responded or are intolerant to methotrexate. It can be used alone or in combination with methotrexate or other non-biologically modifying anti-rheumatic medications (DMARDs). Tofacitinib is indicated for the treatment of adult patients with active psoriatic arthritis who have a poor response or intolerance to methotrexate or other disease-modifying antirheumatic drugs (DMARD). Tofacitinib is approved for the treatment of adult patients with moderate to severe active ulcerative colitis (UC). Pharmacology Tofacitinib is a JAK inhibitor that is partially reversible and prevents the body from responding to cytokine signals. Tofacitinib prevents STAT phosphorylation and activation by inhibiting JAK. The JAK-STAT signaling pathway regulates cell transcription in hematopoietic and immune cell functions. Tofacitinib works as an anti-inflammatory agent by inhibiting the JAK-STAT pathway. However, there is evidence that it can also have other healing effects. Rheumatoid arthritis is an autoimmune disease characterized by pro-inflammatory cytokine dysregulation, including IL7, IL15, IL21, IL6, IFN, and IFN. (3) Through the Janus kinase signaling pathway, cytokine signaling promotes the recruitment and activation of immune cells, resulting in tissue inflammation and joint damage. Dosage & Administration Tofacitinib 5 mg twice daily or Tofacitinib 11 mg once daily for rheumatoid arthritis. Tofacitinib 5 mg once daily is recommended in patients with moderate to severe renal impairment or moderate hepatic impairment. Tofacitinib 5 mg twice daily or Tofacitinib 11 mg once daily for psoriatic arthritis (in combination with nonbiologic DMARDs). Tofacitinib 5 mg once daily is recommended in patients with moderate to severe renal impairment or moderate hepatic impairment. Tofacitinib 10 mg twice daily for at least 8 weeks, followed by 5 or 10 mg twice daily. If an adequate therapeutic benefit is not obtained after 16 weeks of 10 mg twice daily, discontinue. To maintain response, use the lowest effective dose. Interaction Cytochrome P450 3A4 (CYP3A4) inhibitors of high potency (e.g., Ketoconazole) Tofacitinib 5 mg once daily is the recommended dose: One or more concurrent medications that result in both moderate CYP3A4 inhibition and potent CYP2C19 inhibition (e.g., fluconazole) Tofacitinib 5 mg once daily is the recommended dose. Rifampin and other CYP inducers: Clinical response may be lost or reduced as a result. Side Effects Upper respiratory tract infections, headache, diarrhea, and nasopharyngitis were the most commonly reported adverse reactions during the first 3 months of controlled clinical trials (occurring in more than or equal to 2% of patients treated with Tofacitinib monotherapy or in combination with DMARDs). Pregnancy & Lactation Pregnancy category C. There are no adequate and well-controlled studies of pregnant women. Tofacitinib should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether tofacitinib is excreted in human milk. Since many drugs are excreted in human milk, and because tofacitinib may have serious adverse reactions to nursing babies, it is necessary to decide whether to stop breastfeeding or the drug, taking into account the importance of the drug for breastfeeding. Precautions & Warnings Tofacitinib should not be used during active severe infections, including local infections. Use with caution in patients at high risk of gastrointestinal perforation. Laboratory testing is advised because lymphocytes, neutrophils, hemoglobin, liver enzymes, and lipids can all change. Vaccine: Tofacitinib should not be used with live vaccines. If the absolute lymphocyte count (ALC) is less than 500 cells/mm3, the absolute neutrophil count (ANC) is less than 1000 cells/mm3, or the hemoglobin level is less than 9 g/dL. Storage Conditions Do not store at temperatures above 30°C. Keep out of children's reach. Ratings & Reviews No review Check our pricing section for Tofanib XR 11mg price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confermation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any. Wechat ID: Oronnospark